Structural basis of ferroportin inhibition by minihepcidin PR73

Ferroportin (Fpn) is the only known iron exporter in humans and is essential for maintaining iron homeostasis. Fpn activity is suppressed by hepcidin, an endogenous peptide hormone, which inhibits iron export and promotes endocytosis of Fpn. Hepcidin deficiency leads to hemochromatosis and iron-load...

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Detalles Bibliográficos
Autores principales: Wilbon, Azaan Saalim, Shen, Jiemin, Ruchala, Piotr, Zhou, Ming, Pan, Yaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882908/
https://www.ncbi.nlm.nih.gov/pubmed/36649314
http://dx.doi.org/10.1371/journal.pbio.3001936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882908/
https://www.ncbi.nlm.nih.gov/pubmed/36649314
http://dx.doi.org/10.1371/journal.pbio.3001936

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