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ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells

Alkaliptosis is a recently discovered type of pH-dependent cell death used for tumor therapy. However, its underlying molecular mechanisms and regulatory networks are largely unknown. Here, we report that the acetate-activating enzyme acetyl-CoA short-chain synthase family member 2 (ACSS2) is a posi...

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Detalles Bibliográficos
Autores principales: Que, Dongwen, Kuang, Feimei, Kang, Rui, Tang, Daolin, Liu, Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883393/
https://www.ncbi.nlm.nih.gov/pubmed/36707625
http://dx.doi.org/10.1038/s41598-023-28261-4