Chromatin complex dependencies reveal targeting opportunities in leukemia

Chromatin regulators are frequently mutated in human cancer and are attractive drug targets. They include diverse proteins that share functional domains and assemble into related multi-subunit complexes. To investigate functional relationships among these regulators, here we apply combinatorial CRIS...

Descripción completa

Detalles Bibliográficos
Autores principales: Najm, Fadi J., DeWeirdt, Peter, Moore, Molly M., Bevill, Samantha M., El Farran, Chadi A., Macias, Kevin A., Hegde, Mudra, Waterbury, Amanda L., Liau, Brian B., van Galen, Peter, Doench, John G., Bernstein, Bradley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883437/
https://www.ncbi.nlm.nih.gov/pubmed/36707513
http://dx.doi.org/10.1038/s41467-023-36150-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883437/
https://www.ncbi.nlm.nih.gov/pubmed/36707513
http://dx.doi.org/10.1038/s41467-023-36150-7

Ejemplares similares