Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

BACKGROUND: PICALM is one of the most significant susceptibility factors for Alzheimer’s disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-brain barr...

Descripción completa

Detalles Bibliográficos
Autores principales: Kisler, Kassandra, Sagare, Abhay P., Lazic, Divna, Bazzi, Sam, Lawson, Erica, Hsu, Ching-Ju, Wang, Yaoming, Ramanathan, Anita, Nelson, Amy R., Zhao, Zhen, Zlokovic, Berislav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883925/
https://www.ncbi.nlm.nih.gov/pubmed/36707892
http://dx.doi.org/10.1186/s13024-023-00597-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883925/
https://www.ncbi.nlm.nih.gov/pubmed/36707892
http://dx.doi.org/10.1186/s13024-023-00597-5

Ejemplares similares