Cargando…

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

BACKGROUND: PICALM is one of the most significant susceptibility factors for Alzheimer’s disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-brain barr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kisler, Kassandra, Sagare, Abhay P., Lazic, Divna, Bazzi, Sam, Lawson, Erica, Hsu, Ching-Ju, Wang, Yaoming, Ramanathan, Anita, Nelson, Amy R., Zhao, Zhen, Zlokovic, Berislav V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883925/ https://www.ncbi.nlm.nih.gov/pubmed/36707892 http://dx.doi.org/10.1186/s13024-023-00597-5

Ejemplares similares

Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
por: Kisler, Kassandra, et al.
Publicado: (2023)

Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance
por: Zhao, Zhen, et al.
Publicado: (2015)

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo
por: Nelson, Amy R., et al.
Publicado: (2020)

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
por: Nikolakopoulou, Angeliki M., et al.
Publicado: (2019)

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1
por: Ramanathan, Anita, et al.
Publicado: (2015)

Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling
por: Kisler, Kassandra, et al.
Publicado: (2020)

Corrigendum: Acute ablation of cortical pericytes leads to rapid neurovascular uncoupling
por: Kisler, Kassandra, et al.
Publicado: (2022)

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain
por: Kisler, Kassandra, et al.
Publicado: (2017)

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice
por: Lazic, Divna, et al.
Publicado: (2019)

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C
por: Huuskonen, Mikko T., et al.
Publicado: (2021)

Microglia have a grip on brain microvasculature
por: Kisler, Kassandra, et al.
Publicado: (2021)

Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A
por: Nikolakopoulou, Angeliki Maria, et al.
Publicado: (2021)

3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice
por: Wang, Yaoming, et al.
Publicado: (2022)

A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice
por: Barisano, Giuseppe, et al.
Publicado: (2022)

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease
por: Sweeney, Melanie D, et al.
Publicado: (2015)

Pericyte loss influences Alzheimer-like neurodegeneration in mice
por: Sagare, Abhay P., et al.
Publicado: (2013)

Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice
por: Sagare, Abhay P., et al.
Publicado: (2023)

Brain barriers and their potential role in migraine pathophysiology
por: Wiggers, Astrid, et al.
Publicado: (2022)

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
por: Ma, Qingyi, et al.
Publicado: (2018)

Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
por: Ma, Qingyi, et al.
Publicado: (2022)

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform
por: Parikh, Ishita, et al.
Publicado: (2014)

Association of Alzheimer’s disease risk variants on the PICALM gene with PICALM expression, core biomarkers, and feature neurodegeneration
por: Xu, Wei, et al.
Publicado: (2020)

Genetics of PICALM Expression and Alzheimer's Disease
por: Parikh, Ishita, et al.
Publicado: (2014)

PICALM and Alzheimer’s Disease: An Update and Perspectives
por: Ando, Kunie, et al.
Publicado: (2022)

A yeast model for amyloid-β aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity
por: D’Angelo, Fabien, et al.
Publicado: (2013)

PICALM modulates autophagy activity and tau accumulation
por: Moreau, Kevin, et al.
Publicado: (2014)

Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline
por: Asanad, Samuel, et al.
Publicado: (2020)

Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline
por: Asanad, Samuel, et al.
Publicado: (2020)

Corrigendum: PICALM modulates autophagy activity and tau accumulation
por: Moreau, Kevin, et al.
Publicado: (2015)

Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis
por: Mercer, Jacob L., et al.
Publicado: (2015)

Severe Malaria and Artesunate Treatment, Norway
por: Mørch, Kristine, et al.
Publicado: (2008)

Artesunate Dosing in Severe Falciparum Malaria
por: Dondorp, Arjen M., et al.
Publicado: (2012)

An Exploratory Study on CLU, CR1 and PICALM and Parkinson Disease
por: Gao, Jianjun, et al.
Publicado: (2011)

PICALM rs3851179 Variants Modulate Left Postcentral Cortex Thickness, CSF Amyloid β42, and Phosphorylated Tau in the Elderly
por: Wu, Zhiwei, et al.
Publicado: (2022)

Evidence that blood–CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen
por: Cowan, Robert P., et al.
Publicado: (2021)

Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults
por: Contreras, Joey Annette, et al.
Publicado: (2023)

Population Pharmacokinetics of Artesunate and Dihydroartemisinin following Intra-Rectal Dosing of Artesunate in Malaria Patients
por: Simpson, Julie A, et al.
Publicado: (2006)

Intravenous Artesunate for Severe Malaria in Travelers, Europe
por: Zoller, Thomas, et al.
Publicado: (2011)

Pre‐referral rectal artesunate for severe malaria
por: Okebe, Joseph, et al.
Publicado: (2014)

Suspected Artesunate Resistant Malaria in South India
por: Akunuri, Shalini, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dftvutohgshl4sqten1jig4jr4