Cargando…

Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis

BACKGROUND: Alzheimer’s disease (AD) is an incurable neurodegenerative disorder characterised by the progressive buildup of toxic amyloid-beta (Aβ) and tau protein aggregates eventually leading to cognitive decline. Recent lines of evidence suggest that an impairment of the glymphatic system (GS), a...

Descripción completa

Detalles Bibliográficos
Autores principales: Ben-Nejma, Inès R. H., Keliris, Aneta J., Vanreusel, Verdi, Ponsaerts, Peter, Van der Linden, Annemie, Keliris, Georgios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883946/
https://www.ncbi.nlm.nih.gov/pubmed/36707887
http://dx.doi.org/10.1186/s13195-023-01175-z