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Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates

Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like properties. Here we show that unlike synaptophysin, other major integral SV membrane proteins fail to form con...

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Detalles Bibliográficos
Autores principales: Park, Daehun, Wu, Yumei, Wang, Xinbo, Gowrishankar, Swetha, Baublis, Aaron, De Camilli, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884207/
https://www.ncbi.nlm.nih.gov/pubmed/36709207
http://dx.doi.org/10.1038/s41467-023-36081-3