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The RESP AI model accelerates the identification of tight-binding antibodies

High-affinity antibodies are often identified through directed evolution, which may require many iterations of mutagenesis and selection to find an optimal candidate. Deep learning techniques hold the potential to accelerate this process but the existing methods cannot provide the confidence interva...

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Detalles Bibliográficos
Autores principales: Parkinson, Jonathan, Hard, Ryan, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884274/
https://www.ncbi.nlm.nih.gov/pubmed/36709319
http://dx.doi.org/10.1038/s41467-023-36028-8