Metamorphism in TDP-43 prion-like domain determines chaperone recognition

The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation arises upon phase de-mixing and transitions from liquid to solid states, following still unknown structural conversions which are primed...

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Detalles Bibliográficos
Autores principales: Carrasco, Jaime, Antón, Rosa, Valbuena, Alejandro, Pantoja-Uceda, David, Mukhi, Mayur, Hervás, Rubén, Laurents, Douglas V., Gasset, María, Oroz, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884275/
https://www.ncbi.nlm.nih.gov/pubmed/36709343
http://dx.doi.org/10.1038/s41467-023-36023-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884275/
https://www.ncbi.nlm.nih.gov/pubmed/36709343
http://dx.doi.org/10.1038/s41467-023-36023-z

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