A design of experiments screen reveals that Clostridium novyi-NT spore germinant sensing is stereoflexible for valine and its analogs

Although Clostridium novyi-NT is an anti-cancer bacterial therapeutic which germinates within hypoxic tumors to kill cancer cells, the actual germination triggers for C. novyi-NT are still unknown. In this study, we screen candidate germinants using combinatorial experimental designs and discover by...

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Detalles Bibliográficos
Autores principales: Sundaresan, Ajitha, Le Ngoc, Mai, Wew, Marvell Ung, Ramkumar, Varsha, Raninga, Prahlad, Sum, Rongji, Cheong, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884283/
https://www.ncbi.nlm.nih.gov/pubmed/36709236
http://dx.doi.org/10.1038/s42003-023-04496-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884283/
https://www.ncbi.nlm.nih.gov/pubmed/36709236
http://dx.doi.org/10.1038/s42003-023-04496-9

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