Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH

Non-alcoholic steatosis (NAFLD) and steatohepatitis (NASH) are two highly prevalent human disorders for which therapy remains suboptimal. Bile acids are signaling molecules acting on two main receptors the Farnesoid-x-receptor (FXR) and G protein coupled receptor GPB AR1. Clinical trials have shown...

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Detalles Bibliográficos
Autores principales: Marchianò, Silvia, Biagioli, Michele, Morretta, Elva, Di Giorgio, Cristina, Roselli, Rosalinda, Bordoni, Martina, Bellini, Rachele, Urbani, Ginevra, Massa, Carmen, Monti, Maria Chiara, Zampella, Angela, Distrutti, Eleonora, Fiorucci, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884292/
https://www.ncbi.nlm.nih.gov/pubmed/36709356
http://dx.doi.org/10.1038/s41598-023-28647-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884292/
https://www.ncbi.nlm.nih.gov/pubmed/36709356
http://dx.doi.org/10.1038/s41598-023-28647-4

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