A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma

BACKGROUND: N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and anti-myeloma properties that are partly expl...

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Detalles Bibliográficos
Autores principales: Jake Shortt, Galettis, Peter, Cheah, Chan Y., Davis, Joanne, Ludford-Menting, Mandy, Link, Emma K., Martin, Jennifer H., Koldej, Rachel, Ritchie, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884426/
https://www.ncbi.nlm.nih.gov/pubmed/36709310
http://dx.doi.org/10.1186/s13148-023-01427-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884426/
https://www.ncbi.nlm.nih.gov/pubmed/36709310
http://dx.doi.org/10.1186/s13148-023-01427-7

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