Cargando…

A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma

BACKGROUND: N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and anti-myeloma properties that are partly expl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jake Shortt, Galettis, Peter, Cheah, Chan Y., Davis, Joanne, Ludford-Menting, Mandy, Link, Emma K., Martin, Jennifer H., Koldej, Rachel, Ritchie, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884426/ https://www.ncbi.nlm.nih.gov/pubmed/36709310 http://dx.doi.org/10.1186/s13148-023-01427-7

Ejemplares similares

N-Methyl Pyrrolidone (NMP) Alleviates Lipopolysaccharide (LPS)-Induced Inflammatory Injury in Articular Chondrocytes
por: Zhu, Xianping, et al.
Publicado: (2018)

Spatial proteomics identifies a spectrum of immune dysregulation in acquired bone marrow failure syndromes
por: Koldej, Rachel M., et al.
Publicado: (2023)

Venetoclax or Ruxolitinib in Pre-Transplant Conditioning Lowers the Engraftment Barrier by Different Mechanisms in Allogeneic Stem Cell Transplant Recipients
por: Davis, Joanne E., et al.
Publicado: (2021)

Building a KATalogue of acetyllysine targeting and function
por: Downey, Michael, et al.
Publicado: (2016)

Effect of N-Methyl-pyrrolidone (NMP) on the Equilibrium Solubility of Meloxicam in Aqueous Media: Correlation, Dissolution Thermodynamics, and Preferential Solvation
por: Tinjacá, Darío A., et al.
Publicado: (2022)

The European Human Biomonitoring Initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) for the aprotic solvents N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP)
por: David, Madlen, et al.
Publicado: (2021)

Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014
por: Ulrich, Nadin, et al.
Publicado: (2018)

Salt Effect on the Isobaric Vapor–Liquid Equilibrium Study of Binary Mixtures H(2)O–NMP (N-Methyl-2-pyrrolidone)
por: Wang, Baorong, et al.
Publicado: (2020)

The BRPF1 bromodomain is a molecular reader of di-acetyllysine
por: Obi, Juliet O., et al.
Publicado: (2020)

Correction to: Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014
por: Ulrich, Nadin, et al.
Publicado: (2019)

Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling
por: Sudhamalla, Babu, et al.
Publicado: (2017)

The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis
por: Shao, Zhicheng, et al.
Publicado: (2016)

Immunotherapeutics in Multiple Myeloma: How Can Translational Mouse Models Help?
por: Cooke, Rachel E., et al.
Publicado: (2019)

Physicochemical Characterization of Polyvinyl Pyrrolidone: A Tale of Two Polyvinyl Pyrrolidones
por: Mireles, Laura Karina, et al.
Publicado: (2020)

Hydrophobic cavity-directed azide-acetyllysine photochemistry for profiling non-histone interacting partners of bromodomain protein 1
por: Kuwik, Jordan, et al.
Publicado: (2022)

Lysine Deacetylase Substrate Selectivity: Distinct Interaction Surfaces Drive Positive and Negative Selection for Residues Following Acetyllysine
por: Toro, Tasha B., et al.
Publicado: (2023)

Zebrafish as model organism for cNMP research
por: Dittmar, Fanni, et al.
Publicado: (2015)

Normalized Polarization Ratios for the Analysis of Cell Polarity
por: Shimoni, Raz, et al.
Publicado: (2014)

N-Methyl-2-Pyrrolidone
Publicado: (2001)

Assessing the Effects of Delay to NMP via Audio Analysis
por: Tsioutas, Konstantinos, et al.
Publicado: (2022)

Influencing factors on the NMP-22 urine assay: an experimental model
por: Miyake, Makito, et al.
Publicado: (2012)

Cyclic Nucleotide (cNMP) Analogues: Past, Present and Future
por: Maronde, Erik
Publicado: (2021)

Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes
por: Al-Amiery, Ahmed A., et al.
Publicado: (2012)

Carfilzomib for relapsed and refractory multiple myeloma
por: Groen, K, et al.
Publicado: (2019)

Treatment of relapsed and refractory multiple myeloma
por: Lee, Ji Hyun, et al.
Publicado: (2020)

Selinexor in relapsed/refractory multiple myeloma
por: Richter, Joshua, et al.
Publicado: (2020)

Nanoporous Microsponge Particles (NMP) of Polysaccharides as Universal Carriers for Biomolecules Delivery
por: Caso, Maria Federica, et al.
Publicado: (2020)

Surface Analyses of PVDF/NMP/[EMIM][TFSI] Solid Polymer Electrolyte
por: Sedlak, Petr, et al.
Publicado: (2021)

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives
por: van Beekum, Cornelius J., et al.
Publicado: (2021)

A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance
por: Elserafy, Menattallah, et al.
Publicado: (2021)

Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy
por: Costacurta, Matteo, et al.
Publicado: (2021)

Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells
por: Cooke, Rachel Elizabeth, et al.
Publicado: (2020)

Relapsed/Refractory Multiple Myeloma: A Review of Available Therapies and Clinical Scenarios Encountered in Myeloma Relapse
por: Bhatt, Parva, et al.
Publicado: (2023)

Metabolic engineering of Escherichia coli for the biosynthesis of 2-pyrrolidone
por: Zhang, Jingwei, et al.
Publicado: (2015)

Plasma nuclear matrix protein (NMP) levels in patients with multiple organ failure
por: Endo, S, et al.
Publicado: (1997)

NMP4 regulates the innate immune response to influenza A virus infection
por: Yang, Shuangshuang, et al.
Publicado: (2020)

Diagnostic and prognostic role of BTA, NMP22, survivin and cytology in urothelial carcinoma
por: Gong, Yu-Wen, et al.
Publicado: (2021)

Suitable Cathode NMP Replacement for Efficient Sustainable Printed Li-Ion Batteries
por: Sliz, Rafal, et al.
Publicado: (2022)

The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer
por: Huang, Changkun, et al.
Publicado: (2022)

Exploring nomophobia with a German adaption of the nomophobia questionnaire (NMP-Q-D)
por: Coenen, Melina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t49u9b6ig05srvk8sd3buu3kk2