PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

We performed single-cell RNA-sequencing and T cell receptor clonotype tracking of breast and ovarian cancer patients treated with the CDK4/6 inhibitor ribociclib and PD-1 blockade. We highlight evidence of two orthogonal treatment-associated phenomena: expansion of T cell effector populations and pr...

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Detalles Bibliográficos
Autores principales: Ali, Lestat R., Garrido-Castro, Ana C., Lenehan, Patrick J., Bollenrucher, Naima, Stump, Courtney T., Dougan, Michael, Goel, Shom, Shapiro, Geoffrey I., Tolaney, Sara M., Dougan, Stephanie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884581/
https://www.ncbi.nlm.nih.gov/pubmed/36688919
http://dx.doi.org/10.1084/jem.20220729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884581/
https://www.ncbi.nlm.nih.gov/pubmed/36688919
http://dx.doi.org/10.1084/jem.20220729

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