Truncated ring-A amaryllidaceae alkaloid modulates the host cell integrated stress response, exhibiting antiviral activity to HSV-1 and SARSCoV-2

The total synthesis of four novel mono-methoxy and hydroxyl substituted ring-A dihydronarciclasine derivatives enabled identification of the 7-hydroxyl derivative as a potent and selective antiviral agent targeting SARSCoV-2 and HSV-1. The concentration of this small molecule that inhibited HSV-1 in...

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Detalles Bibliográficos
Autores principales: McNulty, James, Babu-Dokuburra, Chanti, Scattolon, Jon, Zepeda-Velazquez, Carlos, Wesesky, Maribeth A., Caldwell, Jill K., Zheng, Wenxiao, Milosevic, Jadranka, Kinchington, Paul R., Bloom, David C., Nimgaonkar, Vishwajit L., D’Aiuto, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885069/
https://www.ncbi.nlm.nih.gov/pubmed/36717567
http://dx.doi.org/10.1038/s41598-023-28691-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885069/
https://www.ncbi.nlm.nih.gov/pubmed/36717567
http://dx.doi.org/10.1038/s41598-023-28691-0

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