Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration

Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. vivax radical cure and prevention of malaria transmission. PQ is a racemic drug and since the metabolism and pharmacology of PQ’s...

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Detalles Bibliográficos
Autores principales: Khan, Washim, Wang, Yan-Hong, Chaurasiya, Narayan D., Nanayakkara, N. P. Dhammika, Bandara Herath, H. M., Harrison, Kerri A., Dale, Gray, Stanford, Donald A., Dahl, Eric P., McChesney, James D., Gul, Waseem, ElSohly, Mahmoud A., Jollow, David, Tekwani, Babu L., Walker, Larry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885159/
https://www.ncbi.nlm.nih.gov/pubmed/36726785
http://dx.doi.org/10.3389/fphar.2022.1104735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885159/
https://www.ncbi.nlm.nih.gov/pubmed/36726785
http://dx.doi.org/10.3389/fphar.2022.1104735

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