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Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration
Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. vivax radical cure and prevention of malaria transmission. PQ is a racemic drug and since the metabolism and pharmacology of PQ’s...
Autores principales: | Khan, Washim, Wang, Yan-Hong, Chaurasiya, Narayan D., Nanayakkara, N. P. Dhammika, Bandara Herath, H. M., Harrison, Kerri A., Dale, Gray, Stanford, Donald A., Dahl, Eric P., McChesney, James D., Gul, Waseem, ElSohly, Mahmoud A., Jollow, David, Tekwani, Babu L., Walker, Larry A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885159/ https://www.ncbi.nlm.nih.gov/pubmed/36726785 http://dx.doi.org/10.3389/fphar.2022.1104735 |
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