Cargando…

Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer

BACKGROUND: Genetic background plays an important role in the occurrence and development of gastric cancer (GC). With the application of genome-wide association study (GWAS), an increasing number of tumor susceptibility genes in gastric cancer have been discovered. While little of them can be furthe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yuqi, Yan, Wenying, Yang, Kexi, Qian, Yiting, Chen, Yanjun, Wang, Ruoqin, Zhu, Jinghan, He, Yuxin, Wu, Hongya, Zhang, Guangbo, Shi, Tongguo, Chen, Weichang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885627/ https://www.ncbi.nlm.nih.gov/pubmed/36710342 http://dx.doi.org/10.1186/s13046-023-02611-6

Ejemplares similares

H19 promotes aerobic glycolysis, proliferation, and immune escape of gastric cancer cells through the microRNA‐519d‐3p/lactate dehydrogenase A axis
por: Sun, Linqing, et al.
Publicado: (2021)

Circular RNA circLDLR facilitates cancer progression by altering the miR-30a-3p/SOAT1 axis in colorectal cancer
por: Wang, Ruoqin, et al.
Publicado: (2022)

B7-H3 suppresses doxorubicin-induced senescence-like growth arrest in colorectal cancer through the AKT/TM4SF1/SIRT1 pathway
por: Wang, Ruoqin, et al.
Publicado: (2021)

B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression
por: Wang, Ruoqin, et al.
Publicado: (2020)

Evaluation of plasma exosomal microRNAs as circulating biomarkers for progression and metastasis of gastric cancer
por: Chen, Yuqi, et al.
Publicado: (2020)

B7-H5 blockade enhances CD8(+) T-cell-mediated antitumor immunity in colorectal cancer
por: Wang, Jiayu, et al.
Publicado: (2021)

B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer
por: Ma, Yanchao, et al.
Publicado: (2020)

HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification
por: Wang, Jiayu, et al.
Publicado: (2023)

Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice
por: Yu, Hongwei, et al.
Publicado: (2007)

MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey
por: Yan, Wenying, et al.
Publicado: (2023)

Genkwadaphnin inhibits growth and invasion in hepatocellular carcinoma by blocking DHCR24-mediated cholesterol biosynthesis and lipid rafts formation
por: Wu, Jie, et al.
Publicado: (2020)

DPP4 Regulates DHCR24-Mediated Cholesterol Biosynthesis to Promote Methotrexate Resistance in Gestational Trophoblastic Neoplastic Cells
por: Yuan, Weijie, et al.
Publicado: (2021)

Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2(+) diffuse large B-cell lymphomas
por: Shen, Yajie, et al.
Publicado: (2022)

B7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A: Erratum
por: Ma, Yanchao, et al.
Publicado: (2020)

B7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A
por: Ma, Yanchao, et al.
Publicado: (2020)

B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2
por: Shi, Tongguo, et al.
Publicado: (2019)

B7H3 increases ferroptosis resistance by inhibiting cholesterol metabolism in colorectal cancer
por: Jin, Haiyan, et al.
Publicado: (2023)

The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis
por: Bai, Xiaojing, et al.
Publicado: (2022)

B7-H4 expression is upregulated by PKCδ activation and contributes to PKCδ-induced cell motility in colorectal cancer
por: Zhou, Bin, et al.
Publicado: (2022)

Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma
por: Dai, Miao, et al.
Publicado: (2017)

B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells
por: Lu, Huimin, et al.
Publicado: (2020)

DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex
por: Zheng, Huifei Sophia, et al.
Publicado: (2023)

Identification of MicroRNAs as Potential Biomarker for Gastric Cancer by System Biological Analysis
por: Yan, Wenying, et al.
Publicado: (2014)

Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization
por: Huang, Yue, et al.
Publicado: (2023)

OR19-1 Ncor1 Regulates the Expression of Dhcr24, which Controls de novo Cholesterol Synthesis in the Adrenal Gland Inner Cortex
por: Huang, Chen-Che Jeff, et al.
Publicado: (2022)

Downregulation of CD40 expression contributes to the accumulation of myeloid-derived suppressor cells in gastric tumors
por: SHEN, JIN, et al.
Publicado: (2014)

Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24(−/−) Mice
por: Kuehnle, Katrin, et al.
Publicado: (2009)

Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
por: Cecchi, C, et al.
Publicado: (2008)

Virtual Screening of Novel 24-Dehydroxysterol Reductase (DHCR24) Inhibitors and the Biological Evaluation of Irbesartan in Cholesterol-Lowering Effect
por: Wang, Haozhen, et al.
Publicado: (2023)

Comparison of Prognostic MicroRNA Biomarkers in Blood and Tissues for Gastric Cancer
por: Yan, Wenying, et al.
Publicado: (2016)

CD40 controls CXCR5-induced recruitment of myeloid-derived suppressor cells to gastric cancer
por: Ding, Yixin, et al.
Publicado: (2015)

RETRACTED ARTICLE: Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24(−/−) Mice
por: Kuehnle, Katrin, et al.
Publicado: (2008)

Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation
por: Suzuki, Akiko, et al.
Publicado: (2020)

B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway
por: Xia, Lu, et al.
Publicado: (2023)

DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice
por: Zhang, Wen-bin, et al.
Publicado: (2023)

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
por: Martiskainen, Henna, et al.
Publicado: (2017)

High DHCR7 Expression Predicts Poor Prognosis for Cervical Cancer
por: Zou, Jing, et al.
Publicado: (2022)

DHCR7 Expression Predicts Poor Outcomes and Mortality from Sepsis
por: Guirgis, Faheem W., et al.
Publicado: (2023)

DHCR7 Expression Predicts Poor Outcomes and Mortality From Sepsis
por: Guirgis, Faheem W., et al.
Publicado: (2023)

Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
por: Zhou, Enchen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_imvesvg605fcsk6lngmfv3f02a