UCP2-dependent redox sensing in POMC neurons regulates feeding

Paradoxically, glucose, the primary driver of satiety, activates a small population of anorexigenic pro-opiomelanocortin (POMC) neurons. Here, we show that lactate levels in the circulation and in the cerebrospinal fluid are elevated in the fed state and the addition of lactate to glucose activates...

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Detalles Bibliográficos
Autores principales: Yoon, Nal Ae, Jin, Sungho, Kim, Jung Dae, Liu, Zhong Wu, Sun, Qiushi, Cardone, Rebecca, Kibbey, Richard, Diano, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885759/
https://www.ncbi.nlm.nih.gov/pubmed/36577374
http://dx.doi.org/10.1016/j.celrep.2022.111894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885759/
https://www.ncbi.nlm.nih.gov/pubmed/36577374
http://dx.doi.org/10.1016/j.celrep.2022.111894

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