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Early transcriptional and epigenetic divergence of CD8(+) T cells responding to acute versus chronic infection
During a microbial infection, responding CD8(+) T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained protection. An alternative outcome is exhaustion, a state of T cell dysfunction that occurs in the context of chronic infections and cancer. Alt...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886247/ https://www.ncbi.nlm.nih.gov/pubmed/36716323 http://dx.doi.org/10.1371/journal.pbio.3001983 |