Early transcriptional and epigenetic divergence of CD8(+) T cells responding to acute versus chronic infection

During a microbial infection, responding CD8(+) T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained protection. An alternative outcome is exhaustion, a state of T cell dysfunction that occurs in the context of chronic infections and cancer. Alt...

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Detalles Bibliográficos
Autores principales: Quezada, Lauren K., Jin, Wenhao, Liu, Yi Chia, Kim, Eleanor S., He, Zhaoren, Indralingam, Cynthia S., Tysl, Tiffani, Labarta-Bajo, Lara, Wehrens, Ellen J., Jo, Yeara, Kazane, Katelynn R., Hattori, Christopher, Zuniga, Elina I., Yeo, Gene W., Chang, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886247/
https://www.ncbi.nlm.nih.gov/pubmed/36716323
http://dx.doi.org/10.1371/journal.pbio.3001983

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