New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies

Fifteen quinazoline derivatives were designed and synthesized as DNA intercalators. The cytotoxicity of the designed members was assessed against HCT-116 and HepG2 cancer cell lines. In addition, the topoisomerase II (Topo II) inhibitory effect was assessed. Compound 16 was the most cytotoxic and To...

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Detalles Bibliográficos
Autores principales: Gaber, Ahmed A., Sobhy, Mohamed, Turky, Abdallah, Eldehna, Wagdy M., El-Sebaey, Samiha A., El-Metwally, Souad A., El-Naggar, Abeer M., Ibrahim, Ibrahim M., Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886266/
https://www.ncbi.nlm.nih.gov/pubmed/36716311
http://dx.doi.org/10.1371/journal.pone.0274081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886266/
https://www.ncbi.nlm.nih.gov/pubmed/36716311
http://dx.doi.org/10.1371/journal.pone.0274081

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