Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin

The peptide antibiotic albicidin is a DNA topoisomerase inhibitor with low-nanomolar bactericidal activity towards fluoroquinolone-resistant Gram-negative pathogens. However, its mode of action is poorly understood. We determined a 2.6 Å resolution cryoelectron microscopy structure of a ternary comp...

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Detalles Bibliográficos
Autores principales: Michalczyk, Elizabeth, Hommernick, Kay, Behroz, Iraj, Kulike, Marcel, Pakosz-Stępień, Zuzanna, Mazurek, Lukasz, Seidel, Maria, Kunert, Maria, Santos, Karine, von Moeller, Holger, Loll, Bernhard, Weston, John B., Mainz, Andi, Heddle, Jonathan G., Süssmuth, Roderich D., Ghilarov, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886550/
https://www.ncbi.nlm.nih.gov/pubmed/36741192
http://dx.doi.org/10.1038/s41929-022-00904-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886550/
https://www.ncbi.nlm.nih.gov/pubmed/36741192
http://dx.doi.org/10.1038/s41929-022-00904-1

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