Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer’s disease

In the present study, we investigated the effects of urolithin A (UA), a metabolite generated from ellagic acid via its metabolism by gut bacteria, as an autophagy activator with potential neuroprotective activity. WT and 3xTg-AD mice were administered long-term intermittent dietary supplementation...

Descripción completa

Detalles Bibliográficos
Autores principales: Ballesteros-Álvarez, Josué, Nguyen, Wynnie, Sivapatham, Renuka, Rane, Anand, Andersen, Julie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886708/
https://www.ncbi.nlm.nih.gov/pubmed/36576642
http://dx.doi.org/10.1007/s11357-022-00708-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886708/
https://www.ncbi.nlm.nih.gov/pubmed/36576642
http://dx.doi.org/10.1007/s11357-022-00708-y

Ejemplares similares