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Radiosynthesis and preclinical evaluation of [(11)C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging
BACKGROUND: The molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress conditions. It is a homodimer with ATP-dependent activity, and is a prominent member of the chaperone machinery that stabilizes, matures and (re)folds an...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886718/ https://www.ncbi.nlm.nih.gov/pubmed/36715827 http://dx.doi.org/10.1186/s41181-023-00189-0 |