The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner

SIRT3 is a longevity factor that acts as the primary deacetylase in mitochondria. Although ubiquitously expressed, previous global SIRT3 knockout studies have shown primarily a cardiac-specific phenotype. Here, we sought to determine how specifically knocking out SIRT3 in cardiomyocytes (SIRTcKO mic...

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Detalles Bibliográficos
Autores principales: Li, Ping, Newhardt, Maria F., Matsuzaki, Satoshi, Eyster, Craig, Pranay, Atul, Peelor, Frederick F., Batushansky, Albert, Kinter, Caroline, Subramani, Kumar, Subrahmanian, Sandeep, Ahamed, Jasimuddin, Yu, Pengchun, Kinter, Michael, Miller, Benjamin F., Humphries, Kenneth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886736/
https://www.ncbi.nlm.nih.gov/pubmed/36460774
http://dx.doi.org/10.1007/s11357-022-00695-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886736/
https://www.ncbi.nlm.nih.gov/pubmed/36460774
http://dx.doi.org/10.1007/s11357-022-00695-0

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