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BACE1: A Key Regulator in Alzheimer’s Disease Progression and Current Development of its Inhibitors
Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease with no specific disease-modifying treatment. β-secretase (BACE1) is considered the potential and rationale target because it is involved in the rate-limiting step, which produces toxic Aβ(42) peptides that leads to deposits...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886827/ https://www.ncbi.nlm.nih.gov/pubmed/34852746 http://dx.doi.org/10.2174/1570159X19666211201094031 |