Split luciferase-based assay to detect botulinum neurotoxins using hiPSC-derived motor neurons

Botulinum neurotoxins (BoNTs) have been widely used clinically as a muscle relaxant. These toxins target motor neurons and cleave proteins essential for neurotransmitter release like Synaptosomal-associated protein of 25 kDa (SNAP-25). In vitro assays for BoNT testing using rodent cells or immortali...

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Detalles Bibliográficos
Autores principales: Cotter, Laurent, Yu, Feifan, Roqueviere, Sylvain, Duchesne de Lamotte, Juliette, Krupp, Johannes, Dong, Min, Nicoleau, Camille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886929/
https://www.ncbi.nlm.nih.gov/pubmed/36717690
http://dx.doi.org/10.1038/s42003-023-04495-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886929/
https://www.ncbi.nlm.nih.gov/pubmed/36717690
http://dx.doi.org/10.1038/s42003-023-04495-w

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