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Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization

Self-assembly of macromolecules into higher-order symmetric structures is fundamental for the regulation of biological processes. Higher-order symmetric structure self-assembly by the gene expression machinery, such as bacterial DNA-dependent RNA polymerase (RNAP), has never been reported before. He...

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Detalles Bibliográficos
Autores principales: Morichaud, Zakia, Trapani, Stefano, Vishwakarma, Rishi K., Chaloin, Laurent, Lionne, Corinne, Lai-Kee-Him, Joséphine, Bron, Patrick, Brodolin, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886945/
https://www.ncbi.nlm.nih.gov/pubmed/36717560
http://dx.doi.org/10.1038/s41467-023-36113-y