Decreased sensitivity of cyclin-dependent kinase 4/6 inhibitors, palbociclib and abemaciclib to canine lymphoma cells with high p16 protein expression and low retinoblastoma protein phosphorylation

Canine lymphoma/leukemia cell lines with p16 protein expressions: high (17–71 and GL-1) and low (CLBL-1, CLC, Nody-1, and UL-1) were treated in vitro with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, palbociclib or abemaciclib. Cell proliferation decreased as a result, with higher IC(50) lev...

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Detalles Bibliográficos
Autores principales: MAYLINA, Leni, KAMBAYASHI, Satoshi, BABA, Kenji, IGASE, Masaya, MIZUNO, Takuya, OKUDA, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887221/
https://www.ncbi.nlm.nih.gov/pubmed/36450591
http://dx.doi.org/10.1292/jvms.22-0498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887221/
https://www.ncbi.nlm.nih.gov/pubmed/36450591
http://dx.doi.org/10.1292/jvms.22-0498

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