Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test Strips

During a household-transmission field study using COVID-19 antigen rapid diagnostic tests (Ag-RDT), a common test strip lot was identified among 3 participants with false-positive results. In blinded laboratory evaluation, this lot exhibited a significantly higher false-positive rate than other lots...

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Autores principales: Carter, Alyssa M, Viloria Winnett, Alexander, Romano, Anna E, Akana, Reid, Shelby, Natasha, Ismagilov, Rustem F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887260/
https://www.ncbi.nlm.nih.gov/pubmed/36726541
http://dx.doi.org/10.1093/ofid/ofac701
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author Carter, Alyssa M
Viloria Winnett, Alexander
Romano, Anna E
Akana, Reid
Shelby, Natasha
Ismagilov, Rustem F
author_facet Carter, Alyssa M
Viloria Winnett, Alexander
Romano, Anna E
Akana, Reid
Shelby, Natasha
Ismagilov, Rustem F
author_sort Carter, Alyssa M
collection PubMed
description During a household-transmission field study using COVID-19 antigen rapid diagnostic tests (Ag-RDT), a common test strip lot was identified among 3 participants with false-positive results. In blinded laboratory evaluation, this lot exhibited a significantly higher false-positive rate than other lots. Because a positive Ag-RDT result often prompts action, reducing lot-specific false positives can maintain confidence and actionability of true-positive Ag-RDT results.
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spelling pubmed-98872602023-01-31 Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test Strips Carter, Alyssa M Viloria Winnett, Alexander Romano, Anna E Akana, Reid Shelby, Natasha Ismagilov, Rustem F Open Forum Infect Dis Brief Report During a household-transmission field study using COVID-19 antigen rapid diagnostic tests (Ag-RDT), a common test strip lot was identified among 3 participants with false-positive results. In blinded laboratory evaluation, this lot exhibited a significantly higher false-positive rate than other lots. Because a positive Ag-RDT result often prompts action, reducing lot-specific false positives can maintain confidence and actionability of true-positive Ag-RDT results. Oxford University Press 2023-01-05 /pmc/articles/PMC9887260/ /pubmed/36726541 http://dx.doi.org/10.1093/ofid/ofac701 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Carter, Alyssa M
Viloria Winnett, Alexander
Romano, Anna E
Akana, Reid
Shelby, Natasha
Ismagilov, Rustem F
Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test Strips
title Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test Strips
title_full Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test Strips
title_fullStr Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test Strips
title_full_unstemmed Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test Strips
title_short Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test Strips
title_sort laboratory evaluation links some false-positive covid-19 antigen test results observed in a field study to a specific lot of test strips
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887260/
https://www.ncbi.nlm.nih.gov/pubmed/36726541
http://dx.doi.org/10.1093/ofid/ofac701
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