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Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle

RNA interference is a promising therapeutical approach presently hindered by delivery concerns such as rapid RNA degradation and targeting of individual tissues. Injectable hydrogels are one potentially simple and direct route towards overcoming these barriers. Here we report on the utility of a com...

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Detalles Bibliográficos
Autores principales: Ngarande, Ellen, Doubell, Emma, Tamgue, Ousman, Mano, Manuel, Human, Paul, Giacca, Mauro, Davies, Neil Hamer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887344/
https://www.ncbi.nlm.nih.gov/pubmed/36726610
http://dx.doi.org/10.1093/rb/rbac101