Cargando…

A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions

BACKGROUND: Dietary supplementation with a blend of functional amino acids (AA) and grape extract polyphenols contributes to preserve intestinal health and growth performance of piglets during the post-weaning period. In the present experiment, we assessed if a supplementation with a mix of AA and g...

Descripción completa

Detalles Bibliográficos
Autores principales: Fraga, Alícia Zem, Campos, Paulo Henrique Reis Furtado, Hauschild, Luciano, Chalvon-Demersay, Tristan, Beaumont, Martin, Le Floc’h, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887908/
https://www.ncbi.nlm.nih.gov/pubmed/36717823
http://dx.doi.org/10.1186/s12917-023-03580-w
_version_ 1784880434512920576
author Fraga, Alícia Zem
Campos, Paulo Henrique Reis Furtado
Hauschild, Luciano
Chalvon-Demersay, Tristan
Beaumont, Martin
Le Floc’h, Nathalie
author_facet Fraga, Alícia Zem
Campos, Paulo Henrique Reis Furtado
Hauschild, Luciano
Chalvon-Demersay, Tristan
Beaumont, Martin
Le Floc’h, Nathalie
author_sort Fraga, Alícia Zem
collection PubMed
description BACKGROUND: Dietary supplementation with a blend of functional amino acids (AA) and grape extract polyphenols contributes to preserve intestinal health and growth performance of piglets during the post-weaning period. In the present experiment, we assessed if a supplementation with a mix of AA and grape extract polyphenols during the post-weaning period would persist to improve the pig capacity to cope with a subsequent challenge caused by poor hygiene of housing conditions. Eighty pigs weaned at 28 days of age were fed a standard diet supplemented (AAP) or not (CNT) with 0.2% of a blend of AA (glutamine, arginine, cystine, valine, isoleucine, and leucine) and grape extract polyphenols during the post-weaning period (from week 0 to 6). At week 6, pigs were transferred to a growing unit where 50% of pigs previously fed AAP and CNT diets were housed in good and the other 50% in poor hygiene conditions for 3 weeks (from week 7 to 9; challenge period). All pigs were fed a standard growing diet that was not supplemented with AAP. We measured pig growth performance, plasma indicators of inflammation, digestive integrity, and oxidative status, and scored fecal consistency. Differences were considered significant at P ≤ 0.05. RESULTS: One week post-weaning, pigs fed AAP had lower plasma concentrations of haptoglobin than CNT pigs (P = 0.03). Six weeks post-weaning, plasma concentrations of diamine oxidase (DAO) were lower (P = 0.03) whereas those of vitamin E and A were greater (P ≤ 0.05) in pigs fed AAP compared to CNT pigs. The prevalence of diarrhea was higher in CNT pigs compared to AAP pigs (P < 0.01). During the challenge period, only pigs previously fed CNT diet had lower growth rate in poor than good conditions (P ≤ 0.05). They had also greater plasma concentrations of haptoglobin and oxidative stress index (OSI) and lower plasma concentrations of vitamin E in poor than good hygiene conditions (P ≤ 0.05). CONCLUSIONS: Pigs fed AAP diet during post-weaning had less diarrhea and plasma concentrations of a digestive integrity marker, as well as greater plasma concentrations of antioxidant indicators during the post-weaning period. The beneficial effects of AAP supplementation persisted after the post-weaning period as evidenced by the absence of effects of the hygiene challenge on growth and health indicators in pigs previously fed APP. This clearly indicated a greater ability of pigs fed AAP to cope with the poor hygiene conditions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-023-03580-w.
format Online
Article
Text
id pubmed-9887908
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-98879082023-02-01 A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions Fraga, Alícia Zem Campos, Paulo Henrique Reis Furtado Hauschild, Luciano Chalvon-Demersay, Tristan Beaumont, Martin Le Floc’h, Nathalie BMC Vet Res Research BACKGROUND: Dietary supplementation with a blend of functional amino acids (AA) and grape extract polyphenols contributes to preserve intestinal health and growth performance of piglets during the post-weaning period. In the present experiment, we assessed if a supplementation with a mix of AA and grape extract polyphenols during the post-weaning period would persist to improve the pig capacity to cope with a subsequent challenge caused by poor hygiene of housing conditions. Eighty pigs weaned at 28 days of age were fed a standard diet supplemented (AAP) or not (CNT) with 0.2% of a blend of AA (glutamine, arginine, cystine, valine, isoleucine, and leucine) and grape extract polyphenols during the post-weaning period (from week 0 to 6). At week 6, pigs were transferred to a growing unit where 50% of pigs previously fed AAP and CNT diets were housed in good and the other 50% in poor hygiene conditions for 3 weeks (from week 7 to 9; challenge period). All pigs were fed a standard growing diet that was not supplemented with AAP. We measured pig growth performance, plasma indicators of inflammation, digestive integrity, and oxidative status, and scored fecal consistency. Differences were considered significant at P ≤ 0.05. RESULTS: One week post-weaning, pigs fed AAP had lower plasma concentrations of haptoglobin than CNT pigs (P = 0.03). Six weeks post-weaning, plasma concentrations of diamine oxidase (DAO) were lower (P = 0.03) whereas those of vitamin E and A were greater (P ≤ 0.05) in pigs fed AAP compared to CNT pigs. The prevalence of diarrhea was higher in CNT pigs compared to AAP pigs (P < 0.01). During the challenge period, only pigs previously fed CNT diet had lower growth rate in poor than good conditions (P ≤ 0.05). They had also greater plasma concentrations of haptoglobin and oxidative stress index (OSI) and lower plasma concentrations of vitamin E in poor than good hygiene conditions (P ≤ 0.05). CONCLUSIONS: Pigs fed AAP diet during post-weaning had less diarrhea and plasma concentrations of a digestive integrity marker, as well as greater plasma concentrations of antioxidant indicators during the post-weaning period. The beneficial effects of AAP supplementation persisted after the post-weaning period as evidenced by the absence of effects of the hygiene challenge on growth and health indicators in pigs previously fed APP. This clearly indicated a greater ability of pigs fed AAP to cope with the poor hygiene conditions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-023-03580-w. BioMed Central 2023-01-30 /pmc/articles/PMC9887908/ /pubmed/36717823 http://dx.doi.org/10.1186/s12917-023-03580-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Fraga, Alícia Zem
Campos, Paulo Henrique Reis Furtado
Hauschild, Luciano
Chalvon-Demersay, Tristan
Beaumont, Martin
Le Floc’h, Nathalie
A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions
title A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions
title_full A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions
title_fullStr A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions
title_full_unstemmed A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions
title_short A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions
title_sort blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887908/
https://www.ncbi.nlm.nih.gov/pubmed/36717823
http://dx.doi.org/10.1186/s12917-023-03580-w
work_keys_str_mv AT fragaaliciazem ablendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT campospaulohenriquereisfurtado ablendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT hauschildluciano ablendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT chalvondemersaytristan ablendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT beaumontmartin ablendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT leflochnathalie ablendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT fragaaliciazem blendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT campospaulohenriquereisfurtado blendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT hauschildluciano blendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT chalvondemersaytristan blendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT beaumontmartin blendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions
AT leflochnathalie blendoffunctionalaminoacidsandgrapepolyphenolsimprovesthepigcapacitytocopewithaninflammatorychallengecausedbypoorhygieneofhousingconditions