Nonproductive Hepatitis B Virus Covalently Closed Circular DNA Generates HBx-Related Transcripts from the HBx/Enhancer I Region and Acquires Reactivation by Superinfection in Single Cells

Hepatitis B virus (HBV) infection remains a public health problem worldwide. Persistent HBV infection relies on active transcription of the covalently closed circular DNA (cccDNA) in hepatocytes, which is less understood at the single-cell level. In this study, we isolated primary human hepatocytes...

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Detalles Bibliográficos
Autores principales: Peng, Bo, Jing, Zhiyi, Zhou, Zhongmin, Sun, Yinyan, Guo, Guilan, Tan, Zexi, Diao, Yan, Yao, Qiyan, Ping, Yi, Li, Xuelei, Ren, Tengfei, Li, Bin, Li, Wenhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888189/
https://www.ncbi.nlm.nih.gov/pubmed/36475867
http://dx.doi.org/10.1128/jvi.01717-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888189/
https://www.ncbi.nlm.nih.gov/pubmed/36475867
http://dx.doi.org/10.1128/jvi.01717-22

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