Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield

The envelope glycoprotein (Env) is the main focus of human immunodeficiency virus type 1 (HIV-1) vaccine development due to its critical role in viral entry. Despite advances in protein engineering, many Env proteins remain recalcitrant to recombinant expression due to their inherent metastability,...

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Detalles Bibliográficos
Autores principales: Wrapp, Daniel, Mu, Zekun, Thakur, Bhishem, Janowska, Katarzyna, Ajayi, Oluwatobi, Barr, Maggie, Parks, Robert, Mansouri, Katayoun, Edwards, Robert J., Hahn, Beatrice H., Acharya, Priyamvada, Saunders, Kevin O., Haynes, Barton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Structure and Assembly
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888283/
https://www.ncbi.nlm.nih.gov/pubmed/36633409
http://dx.doi.org/10.1128/jvi.01673-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888283/
https://www.ncbi.nlm.nih.gov/pubmed/36633409
http://dx.doi.org/10.1128/jvi.01673-22

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