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Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield
The envelope glycoprotein (Env) is the main focus of human immunodeficiency virus type 1 (HIV-1) vaccine development due to its critical role in viral entry. Despite advances in protein engineering, many Env proteins remain recalcitrant to recombinant expression due to their inherent metastability,...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888283/ https://www.ncbi.nlm.nih.gov/pubmed/36633409 http://dx.doi.org/10.1128/jvi.01673-22 |