A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents

Pain signals are relayed to the brain via a nociceptive system, and in rare cases, this nociceptive system contains genetic variants that can limit the pain response. Here, we questioned whether a human transient receptor potential vanilloid 1 (TRPV1) missense variant causes a resistance to noxious...

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Detalles Bibliográficos
Autores principales: He, Shufang, Zambelli, Vanessa O., Sinharoy, Pritam, Brabenec, Laura, Bian, Yang, Rwere, Freeborn, Hell, Rafaela C.R., Stein Neto, Beatriz, Hung, Barbara, Yu, Xuan, Zhao, Meng, Luo, Zhaofei, Wu, Chao, Xu, Lijun, Svensson, Katrin J., McAllister, Stacy L., Stary, Creed M., Wagner, Nana-Maria, Zhang, Ye, Gross, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888391/
https://www.ncbi.nlm.nih.gov/pubmed/36472910
http://dx.doi.org/10.1172/JCI163735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888391/
https://www.ncbi.nlm.nih.gov/pubmed/36472910
http://dx.doi.org/10.1172/JCI163735

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