Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder

Human platelet 12-lipoxygenase (h12-LOX) is responsible for the formation of oxylipin products that play an important role in platelet aggregation. Single nucleotide polymorphisms (SNPs) of h12-LOX have been implicated in several diseases. In this study, we investigate the structural, dynamical, and...

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Detalles Bibliográficos
Autores principales: Tran, Michelle, Signorelli, Rachel L., Yamaguchi, Adriana, Chen, Eefie, Holinstat, Michael, Iavarone, Anthony T., Offenbacher, Adam R., Holman, Theodore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888433/
https://www.ncbi.nlm.nih.gov/pubmed/36442529
http://dx.doi.org/10.1016/j.abb.2022.109472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888433/
https://www.ncbi.nlm.nih.gov/pubmed/36442529
http://dx.doi.org/10.1016/j.abb.2022.109472

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