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Predictive modeling of concentration-dependent viscosity behavior of monoclonal antibody solutions using artificial neural networks
Solutions of monoclonal antibodies (mAbs) can show increased viscosity at high concentration, which can be a disadvantage during protein purification, filling, and administration. The viscosity is determined by protein-protein-interactions, which are influenced by the antibody’s sequence as well as...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888472/ https://www.ncbi.nlm.nih.gov/pubmed/36705325 http://dx.doi.org/10.1080/19420862.2023.2169440 |