The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells

BACKGROUND: The Rho-kinase ROCK II plays a major role in the activation of hepatic stellate cells (HSC), which are the key profibrotic and contractile cells contributing to the development of chronic liver disease. Inhibition of ROCK II ultimately blocks the phosphorylation of the myosin light chain...

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Detalles Bibliográficos
Autores principales: Bachtler, Nadine, Torres, Sandra, Ortiz, Cristina, Schierwagen, Robert, Tyc, Olaf, Hieber, Christoph, Berres, Marie-Luise, Meier, Caroline, Kraus, Nico, Zeuzem, Stefan, Nijmeijer, Bart, Pronk, Sebas, Trebicka, Jonel, Klein, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888688/
https://www.ncbi.nlm.nih.gov/pubmed/36719899
http://dx.doi.org/10.1371/journal.pone.0270288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888688/
https://www.ncbi.nlm.nih.gov/pubmed/36719899
http://dx.doi.org/10.1371/journal.pone.0270288

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