Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form. Previously we reported a 3.1 Å structure of yeast dynein bound to Pac1, t...

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Detalles Bibliográficos
Autores principales: Reimer, Janice M, DeSantis, Morgan E, Reck-Peterson, Samara L, Leschziner, Andres E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889085/
https://www.ncbi.nlm.nih.gov/pubmed/36692009
http://dx.doi.org/10.7554/eLife.84302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889085/
https://www.ncbi.nlm.nih.gov/pubmed/36692009
http://dx.doi.org/10.7554/eLife.84302

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