A fluorescent multi-domain protein reveals the unfolding mechanism of Hsp70

Detailed understanding of the mechanism by which Hsp70 chaperones protect cells against protein aggregation is hampered by the lack of a comprehensive characterization of the aggregates, which are typically heterogeneous. Here we designed a reporter chaperone substrate, MLucV, composed of a stress-l...

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Detalles Bibliográficos
Autores principales: Tiwari, Satyam, Fauvet, Bruno, Assenza, Salvatore, De Los Rios, Paolo, Goloubinoff, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889267/
https://www.ncbi.nlm.nih.gov/pubmed/36266349
http://dx.doi.org/10.1038/s41589-022-01162-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889267/
https://www.ncbi.nlm.nih.gov/pubmed/36266349
http://dx.doi.org/10.1038/s41589-022-01162-9

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