Structural basis of colibactin activation by the ClbP peptidase

Colibactin, a DNA cross-linking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance mechanism: a non-toxic precursor assembled in the cytoplasm is activated after export to the periplasm. This activation is mediated by ClbP, an inner-membran...

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Detalles Bibliográficos
Autores principales: Velilla, José A., Volpe, Matthew R., Kenney, Grace E., Walsh, Richard M., Balskus, Emily P., Gaudet, Rachelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889268/
https://www.ncbi.nlm.nih.gov/pubmed/36253550
http://dx.doi.org/10.1038/s41589-022-01142-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889268/
https://www.ncbi.nlm.nih.gov/pubmed/36253550
http://dx.doi.org/10.1038/s41589-022-01142-z

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