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Structural basis of colibactin activation by the ClbP peptidase
Colibactin, a DNA cross-linking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance mechanism: a non-toxic precursor assembled in the cytoplasm is activated after export to the periplasm. This activation is mediated by ClbP, an inner-membran...
Autores principales: | Velilla, José A., Volpe, Matthew R., Kenney, Grace E., Walsh, Richard M., Balskus, Emily P., Gaudet, Rachelle |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889268/ https://www.ncbi.nlm.nih.gov/pubmed/36253550 http://dx.doi.org/10.1038/s41589-022-01142-z |
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