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Design principles of improving the dose-response alignment in coupled GTPase switches
“Dose-response alignment” (DoRA), where the downstream response of cellular signaling pathways closely matches the fraction of activated receptor, can improve the fidelity of dose information transmission. The negative feedback has been experimentally identified as a key component for DoRA, but nume...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889403/ https://www.ncbi.nlm.nih.gov/pubmed/36720885 http://dx.doi.org/10.1038/s41540-023-00266-9 |