Estrogen receptor α K303R mutation reorganizes its binding to forkhead box protein A1 regions and induces chromatin opening

BACKGROUND: Estrogen receptor alpha (ERα) is a frequently mutated gene in breast cancer (BC). While many studies have investigated molecular dysregulation by hotspot mutations at Y537 and D538, which exhibit an estrogen-independent constitutively active phenotype, the functional abnormalities of oth...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakadai, Tomoyoshi, Yang, Liying, Kumegawa, Kohei, Maruyama, Reo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889408/
https://www.ncbi.nlm.nih.gov/pubmed/36436079
http://dx.doi.org/10.1007/s11033-022-08089-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889408/
https://www.ncbi.nlm.nih.gov/pubmed/36436079
http://dx.doi.org/10.1007/s11033-022-08089-3

Ejemplares similares