Circulating selenoprotein P levels predict glucose‐lowering and insulinotropic effects of metformin, but not alogliptin: A post‐hoc analysis

AIMS/INTRODUCTION: Selenoprotein P (SeP; encoded by SEPP1 in humans) is a hepatokine that causes impaired insulin secretion and insulin resistance. Metformin downregulates SELENOP promoter activity through an adenosine monophosphate‐activated kinase–forkhead box protein O3a pathway in hepatocytes. T...

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Detalles Bibliográficos
Autores principales: Takeshita, Yumie, Tanaka, Takeo, Takayama, Hiroaki, Kita, Yuki, Goto, Hisanori, Nakano, Yujiro, Saito, Yoshiro, Takamura, Toshinari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889665/
https://www.ncbi.nlm.nih.gov/pubmed/36479595
http://dx.doi.org/10.1111/jdi.13949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889665/
https://www.ncbi.nlm.nih.gov/pubmed/36479595
http://dx.doi.org/10.1111/jdi.13949

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