Enhancing CAR-T cell functionality in a patient-specific manner

Patient responses to autologous CD19 chimeric antigen receptor (CAR) T-cell therapies are limited by insufficient and inconsistent cellular functionality. Here, we show that controlling the precise level of stimulation during T-cell activation to accommodate individual differences in the donor cells...

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Detalles Bibliográficos
Autores principales: Zhang, David K. Y., Adu-Berchie, Kwasi, Iyer, Siddharth, Liu, Yutong, Cieri, Nicoletta, Brockman, Joshua M., Neuberg, Donna, Wu, Catherine J., Mooney, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889707/
https://www.ncbi.nlm.nih.gov/pubmed/36720856
http://dx.doi.org/10.1038/s41467-023-36126-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889707/
https://www.ncbi.nlm.nih.gov/pubmed/36720856
http://dx.doi.org/10.1038/s41467-023-36126-7

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