Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export

Regorafenib (REGO) is a synthetic oral multi-kinase inhibitor with potent antitumor activity. In this study, we investigate the molecular mechanisms by which REGO induces apoptosis. REGO induced cytotoxicity, inhibited the proliferation and migration ability of cells, and induced nuclear condensatio...

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Detalles Bibliográficos
Autores principales: Sun, Beini, Chen, Hongce, Wang, Xiaoping, Chen, Tongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889785/
https://www.ncbi.nlm.nih.gov/pubmed/36720853
http://dx.doi.org/10.1038/s41420-023-01338-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889785/
https://www.ncbi.nlm.nih.gov/pubmed/36720853
http://dx.doi.org/10.1038/s41420-023-01338-9

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