Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants

BACKGROUND: As SARS-CoV-2 continues to mutate into Variants of Concern (VOC), there is growing and urgent need to develop effective antivirals to combat COVID-19. Monoclonal antibodies developed earlier are no longer capable of effectively neutralizing currently active VOCs. This report describes th...

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Detalles Bibliográficos
Autores principales: Bodie, Neil M, Hashimoto, Rina, Connolly, David, Chu, Jennifer, Takayama, Kazuo, Uhal, Bruce D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889962/
https://www.ncbi.nlm.nih.gov/pubmed/36741194
http://dx.doi.org/10.1093/abt/tbad001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889962/
https://www.ncbi.nlm.nih.gov/pubmed/36741194
http://dx.doi.org/10.1093/abt/tbad001

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