Cargando…
Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation
Psoriasis is a chronic autoimmune inflammatory skin disorder characterized by epidermal hyperplasia and aberrant immune response. In addition to aberrant cytokine production, psoriasis is associated with activation of the Akt/mTOR pathway. mTOR/S6K1 regulates T-lymphocyte activation and migration, k...
Autores principales: | Roy, Tithi, Banang-Mbeumi, Sergette, Boateng, Samuel T., Ruiz, Emmanuelle M., Chamcheu, Roxane-Cherille N., Kang, Lin, King, Judy A., Walker, Anthony L., Nagalo, Bolni Marius, Kousoulas, Konstantin G., Esnault, Stephane, Huang, Shile, Chamcheu, Jean Christopher |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889994/ https://www.ncbi.nlm.nih.gov/pubmed/36741386 http://dx.doi.org/10.3389/fimmu.2022.1075804 |
Ejemplares similares
-
Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models
por: Chamcheu, Jean Christopher, et al.
Publicado: (2019) -
Identification of new fisetin analogs as kinase inhibitors: Data on synthesis and anti-skin cancer activities evaluation
por: Roy, Tithi, et al.
Publicado: (2021) -
Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy
por: Chamcheu, Jean Christopher, et al.
Publicado: (2019) -
The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds
por: Roy, Tithi, et al.
Publicado: (2023) -
Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
por: Rady, Islam, et al.
Publicado: (2018)